The nine-room house at 83 Beals St. in Brookline is a national historic site where the 35th American president spent his early boyhood.
The town put a memorial in front of the residence following JFK's 1963 death.
The Kennedy family repurchased the home from other owners a few years later before gifting it to the National Park Service in 1969.
Tours from National Park rangers will include a look at Kennedy family furnishings, photographs and other mementos.
The historic site closes in the winter and reopens to the public next May.